Atlanbio provides comprehensive immunochemistry techniques for compounds in development:
- EIA: (Enzyme Immuno Assay) and ELISA (Enzyme Linked Immuno Sorbent Assay): highly versatile methods that use enzyme-labelled antibodies or antigens to detect the compound of interest (suitable for the analysis of biological drugs and their targets)
- ECLIA (Electro Chemi Luminescence Immuno Assay): Immunoassays with improved sensitivity, dynamic range (up to 4 concentration logs), and decreased matrix effects. Perfectly adapted to the analysis of highly inducible biomarkers (multiplex enabled) and immunogenicity (anti-drug antibodies). Improved performance for the determination of biological drugs and their targets.
Radioactive (125I, 3H, 14C) techniques:
RIA (Radio Immuno Assay): Techniques involving radiolabelled antigens or antibodies. Particularly adapted to the analysis of small biological compounds (therapeutic or endogenous peptides)
Culture of cell lines in adapted conditions and under varying stimuli allowing the detection of neutralizing anti-drug antibodies. Perfect complement to the gold standard “screening, confirmatory and characterization” Immunogenicity approach, for better comprehension of the safety and efficacy of biological compounds.